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专利名称：ARYL IMIDAZOLES AND THEIR USE AS ANTI-CANCER AGENTS
发明人：HUESCA, Mario,AL-QAWASMEH,
Raed,YOUNG, Aiping, H.,LEE, Yoon,LOCK Lisa
申请号：EP04799154.2申请日：20041115公开号：EP1692113B1公开日：20170927
摘要：Therapeutically effective 2,4,5-trisubstituted imidazole compounds areprovided. Also provided are methods of preparing the compounds and pharmaceuticalcompositions comprising the compounds alone or in combination with other agents. Thepresent invention further provides for the use of the compounds as anti-cancer agents;wherein: R1 is aryl, substituted aryl, heterocycle, substituted heterocycle, heteroaryl,substituted heteroaryl or amino; R2 and R3 are independently aryl, substituted aryl,heterocycle, heteroaryl, substituted heterocycle, or substituted heteroaryl or R2 and R3when taken together along with the carbon atoms they are attached to, form aryl orsubstituted aryl, and R4 is hydrogen, halogen, hydroxyl, thiol, lower alkyl, substitutedlower alkyl, lower alkenyl, substituted lower alkenyl, lower alkynyl, substituted loweralkynyl, alkylalkenyl, alkyl alkynyl, alkoxy, alkylthio, aryl, aryloxy, amino, amido, carboxyl,aryl, substituted aryl, heterocycle, heteroaryl, substituted heterocycle, heteroalkyl,cycloalkyl, substituted cycloalkyl, alkylcycloalkyl, alkylcycloheteroalkyl, nitro, cyano or —S(O)0-2R wherein R is alkyl, substituted alkyl, aryl, substituted aryl, heterocycle,heteroaryl, substituted heterocycle, or substituted heteroaryl.
申请人：LORUS THERAPEUTICS INC
地址：CA
国籍：CA
代理机构：Cooley (UK) LLP
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