专利内容由知识产权出版社提供
专利名称：METHODS AND DEVICES FOR PREPARATION
OF LIPID NANOPARTICLES
发明人：ZHU, De-Min申请号：EP14769279.2申请日：20140314公开号：EP2968193A1公开日：20160120
摘要：The present invention provides for a process for preparing liposomes, lipiddiscs, and other lipid nanoparticles using a multi-port manifold, wherein the lipid solutionstream, containing an organic solvent, is mixed with two or more streams of aqueoussolution (e.g., buffer). In some aspects, at least some of the streams of the lipid andaqueous solutions are not directly opposite of each other. Thus, the process does notrequire dilution of the organic solvent as an additional step. In some embodiments, oneof the solutions may also contain an active pharmaceutical ingredient (API). This inventionprovides a robust process of liposome manufacturing with different lipid formulationsand different payloads. Particle size, morphology, and the manufacturing scale can becontrolled by altering the port size and number of the manifold ports, and by selectingthe flow rate or flow velocity of the lipid and aqueous solutions.
申请人：Cureport Inc.
地址：1 Innovation Drive, Suite 450 Worcester MA 01605 US
国籍：US
代理机构：Michalski Hüttermann & Partner Patentanwälte mbB
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