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专利名称：MEDICAMENT WITH DELAYED RELEASE OF
THE ACTIVE SUBSTANCE, CONTAINING 1-DIMETHYLAMINO-3-(3-METHOXY-PHENYL)-2-METHYL-PENTAN-3-OL
发明人：BARTHOLOMAEUS, JOHANNES,ZIEGLER, IRIS申请号：EP037324.7申请日：20030526公开号：EP1507519B1公开日：20060517
摘要：The invention relates to a pharmaceutical formulation with delayed release ofthe agent, containing 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol orone of the pharmaceutically acceptable salts thereof in a matrix. Said matrix contains 1 to80 percent by weight of one or several hydrophilic or hydrophobic polymer/s aspharmaceutically acceptable matrix-forming substance/s and has the followingdissolution rate: 3-35 percent by weight (relative to 100 percent by weight of activesubstance) of 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol are releasedafter 0.5 hours; 5-50 percent by weight of % 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol are released after 1 hour; 10-75 percent by weight of 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol are released after 2 hours;15-82 percent by weight of 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-olare released after 3 hours; 30-97 percent by weight of 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol are released after 6 hours; more than 50 percent by weightof 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol are released after 12
hours; more than 70 percent by weight of 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol are released after 18 hours; more than 80 percent by weight of 1-dimethylamino-3-(3-methoxy-phenyl)-2-methyl-pentan-3-ol are released after 24 hours.
申请人：GRUENENTHAL GMBH,GRUENENTHAL GMBH,GRUENENTHAL GMBH
地址：DE
国籍：DE
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