PdtDtShtProduct Data SheetProduct Name:CAS No.: Cat. No.:MWt:Formula:Purity :Topiramate97240-79-4HY-B0122339.36C12H21NO8S>98%Solubility:DMSO 68 mg/Ml; Water <1 mg/mLMechanisms: Pathways:GPCR/G protein; Target:mGluR Biological Activity:Topiramate is an anticonvulsant that antagonizes GluR5 receptors and acts as a positive allostericmodulator of GABA receptor-mediated currents. Target: GluR5 receptor; GABA receptor Topiramate (Topamax) is a structurally novel broad-spectrum antiepileptic drug (AED) withestablished efficacy as monotherapy or adjunctive therapy in the treatment of adult and paediatricpatients with generalised tonic-clonic seizures, partial seizures with or without generalised seizures,and seizures associated with Lennox-Gastaut syndrome [1]. topiramate has been believed to be atype of antiepileptic drug that blocks spread of seizures. Thus far, the mechanisms of its actionshave been proven to include use-dependent inhibition of voltage-dependent Na+ channels inneronspotentiationofGABA(gammaaminobtricacid)indcedClinflneurons, potentiation of GABA (gamma-amino-butyric acid)-induced Cl- influx, and inhibitory effectsandinhibitoreffectson inward currents by...References:[1]. Lyseng-Williamson KA, et al. Topiramate: a review of its use in the treatment of epilepsy. Drugs.2007;67(15):2231-56. [2]NakamuraJetalTargetpharmacologyoftopiramateanewantiepilepticdrugNihon[2]. Nakamura J, et al. Target pharmacology of topiramate, a new antiepileptic drug. NihonYakurigaku Zasshi. 2000 Jan;115(1):53-7. [3]. Ormrod D, et al. Topiramate: a review of its use in childhood epilepsy. Paediatr Drugs.2001;3(4):293-319. Caution: Not fully tested. For research purposes onlyMedchemexpress LLCwww.medchemexpress.com18Wilkinson Way, Princeton, NJ 08540,USAEmail: info@medchemexpress.com Web: www.medchemexpress.com
