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专利名称：INHIBITOR OF HISTONE
ACETYLTRANSFERASE, ESPECIALLY p300
发明人：Shuki MIZUTANI,Takayuki Yamada申请号：US12901382申请日：20101008
公开号：US20110070653A1公开日：20110324
摘要：An inhibitor of histone acetyltransferase p300 was isolated from human cDNAlibrary and identified as a nuclear protein composed of 855 amino acid residues. It bindsto the cysteine/histidine-rich region of p300, thereby inhibiting the transcriptionalactivation by p300. It also inhibits the transcription activity of p53, with p300 functioningas a coactivator, and inhibits the discontinuance of cell cycle that relies on p53.
申请人：Shuki MIZUTANI,Takayuki Yamada
地址：Chiba JP,Kanagawa JP
国籍：JP,JP
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