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专利名称：Crystalline forms of afatinib monomaleate,
preparation methods and pharmaceuticalcompositions thereof
发明人：Xiaohong Sheng,Jianfeng Zheng,Xiaoxia
Sheng
申请号：US14995605申请日：20160114公开号：US09708301B2公开日：20170718
摘要：The present invention relates to the novel solid forms of Afatinib monomaleateand preparation methods thereof; the solid forms of Afatinib monomaleate of thepresent invention have many improved properties as compared to the known crystallineform of Afatinib salt; and the present invention also relates to pharmaceuticalcompositions containing the novel solid forms of Afatinib monomaleate as well as theuses thereof for treating terminal non-small cell lung cancer (NSCLS) and HER2 positiveadvanced breast cancer.
申请人：Hangzhou Pushai Pharmaceutical Technology Co., LTD.
地址：Hangzhou CN
国籍：CN
代理机构：Sterne, Kessler, Goldstein & Fox PLLC
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