产品说明Protocol
Curcumin analog C1 目录号M9451
化学数据
分子量分子式CAS号储存条件
294.34C19H18O339777-61-23年 -20°C 粉末状
溶解性（25°C）
DMSO ≥ 10mMWater N/AEthanol N/A
生物活性
Curcumin analog C1 is a potent, orally effective transcription factor EB (TFEB) activator. Curcumin analog C1 specifically binds to TFEB at the N terminus and promotes TFEB nuclear translocation without inhibiting MTOR activity. By activating TFEB, C1 enhances autophagy and lysosome biogenesis in vitro and in vivo. Curcumin analog C1 efficiently activated TFEB, enhanced autophagy and lysosomal activity, and reduced APP, APP C-terminal fragments (CTF-β/α), β-amyloid peptides and Tau aggregates in three AD animal models that represent beta-amyloid precursor protein (APP) pathology (5xFAD mice), tauopathy (P301S mice) and the APP/Tau combined pathology (3xTg-AD mice) accompanied by improved synaptic and cognitive function. Knockdown of TFEB and inhibition of lysosomal activity significantly inhibited the effects of C1 on APP and Tau degradation in vitro. In summary, curcumin analog C1 is a potent TFEB activator with promise for the prevention or treatment of AD.
不同实验动物依据体表面积的等效剂量转换表（数据来源于FDA指南）
小鼠
重量 (kg)体表面积 (m2)Km系数
0.020.0073
大鼠0.150.0256
动物B的Km系数动物A的Km系数兔1.80.1512
豚鼠0.40.058
仓鼠0.080.025
狗100.520
动物A (mg/kg) = 动物B (mg/kg) ×
例如，依据体表面积折算法，将白藜芦醇用于小鼠的剂量22.4 mg/kg 换算成大鼠的剂量，需要将22.4 mg/kg 乘以小鼠的Km系数（3），再除以大鼠的Km系数（6），得到白藜芦醇用于大鼠的等效剂量为11.2 mg/kg。
储备液配制
以下数据基于产品分子量，对于特殊产品，请参照COA中的储备液配制条件和说明进行操作。Concentration / Solvent Volume / Mass1 mM5 mM10 mM
1 mg3.3974 mL0.6795 mL0.3397 mL
5 mg16.9872 mL3.3974 mL1.6987 mL
10 mg33.9743 mL6.7949 mL3.3974 mL
参考文献
A small molecule transcription factor EB activator ameliorates beta-amyloid precursor protein and Tau pathology in Alzheimer's disease models.
Song JX, et al. Aging Cell. 2020 Feb;19(2):e13069. PMID: 31858697.
A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition.Song JX, et al. Autophagy. 2016 Aug 2;12(8):1372-. PMID: 27172265.
所有产品仅供科研使用，严禁用于人或动物的治疗等任何其他用途，不为任何个人提供产品和服务。抑制剂化合物库CCK-8 / 蛋白酶抑制剂Cocktail
AbMole中国
