专利内容由知识产权出版社提供
专利名称：INHIBITION OF LYMPHOCYTE ADHERENCE
TO VASCULAR ENDOTHELIUM UTILIZING ANOVEL EXTRACELLULAR MATRIXRECEPTOR-LIGAND INTERACTION
发明人：FRED HUTCHINSON CANCER RESEARCH
CENTER
申请号：EP90913598申请日：19900831公开号：EP04837A4公开日：19930616
摘要：the invention relates to a method for inhibiting the adhesion of a cell to anotherand to interfere with the interaction between the receptor and its ligand extracellularmatrix.the invention is based on the discovery that the extracellular matrix receptoralpha4beta1 promotes the adherence of lymphocytes to endothelial cells via binding toa peptide sequence identified.prior to the present invention, the ligand of the receptorhad not been identified alpha4beta1, just as we didn't know the function of the receptorbinding alpha4beta1 in lymphocytes.by preventing the interaction between the receptorand its ligands alpha4beta1 by use of antibodies or peptides of defined sequence, thepresent invention allows for the first time to respond specifically to the migration oflymphocytes through the vascular endothelium. in the tissue.therefore, the presentinvention provides a clinically useful in the removal of specific immune response in avariety of ways and specific embodiment of the invention, the adherence of lymphocytesto the endothelium may be inhibited in the system or can \éventuellemen t, be
located in specific tissues or regions identified.accordingly, the present invention allowsfor the treatment of diseases involving autoimmune responses as well as other chronic orrelapsing activations of the immune system, including allergies, asthma, and chronicinflammation of the skin and.
申请人：FRED HUTCHINSON CANCER RESEARCH CENTER
地址：1124 COLUMBIA STREET; SEATTLE WASHINGTON 98104
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